Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | In this study, we examine the ability of leukemia microvesicles to induce proliferation in hematopoietic stem progenitor cells (HSPCs) via microRNA-21 dysregulation. | 31429853 | 2020 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | We have shown that antagomiR inhibition of miRNA miR-21 and miR-196b activity is sufficient to ablate MLL-AF9 leukemia stem cells (LSC) in vivo. | 29997117 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | In this study, we utilized the leukaemia cell line K562 as an in vitro cell model to investigate whether miR-21 is involved in X-ray irradiation resistance. | 25242444 | 2015 | ||||
|
0.080 | Biomarker | disease | BEFREE | In this study, we investigated whether miR-21 mediated resistance of the leukaemia cell line K562 to the chemotherapeutic agent daunorubicin (DNR). miR-21 expression was upregulated in the DNR resistant cell line K562/DNR compared to its parental line K562. | 21187093 | 2011 | ||||
|
0.080 | Biomarker | disease | BEFREE | miRNA-21 regulates arsenic-induced anti-leukemia activity in myelogenous cell lines. | 20143188 | 2011 | ||||
|
0.080 | Biomarker | disease | BEFREE | Therefore, exploiting synergistic effects between AMO-miR-21 and Ara-C might be an effective clinical strategy for leukemia chemotherapy. | 20670480 | 2010 | ||||
|
0.080 | Biomarker | disease | BEFREE | The microRNA-21 (miR-21) has been identified as the only miRNA overexpressed in a variety of cancers, including leukemia. | 20141427 | 2010 | ||||
|
0.080 | Biomarker | disease | BEFREE | Collectively, these results provide important new insight into the pathogenesis of NK-cell lymphoma/leukemia and suggest targeting miR-21 and/or miR-155 may represent a useful approach to treating NK-cell lymphoma/leukemia. | 19641183 | 2009 |